{"id":4755,"date":"2025-06-02T19:26:29","date_gmt":"2025-06-02T19:26:29","guid":{"rendered":"https:\/\/hepatology.ca\/?p=4755"},"modified":"2025-06-09T14:03:06","modified_gmt":"2025-06-09T14:03:06","slug":"collaboratively-address-equity-challenges-in-liver-transplantation","status":"publish","type":"post","link":"https:\/\/hepatology.ca\/fr\/2025\/06\/02\/collaboratively-address-equity-challenges-in-liver-transplantation\/","title":{"rendered":"\u00c9quipe Liver AI \u2013 \u00c9laboration d'un cadre pour lutter contre les in\u00e9galit\u00e9s d'acc\u00e8s et de r\u00e9sultats pour les personnes n\u00e9cessitant une transplantation h\u00e9patique au Canada"},"content":{"rendered":"

F\u00e9licitations \u00e0 la Dre Mamatha Bhat (copr\u00e9sidente du comit\u00e9 de recherche de l\u2019ACEF) pour avoir dirig\u00e9 un projet $2M financ\u00e9 par les IRSC en tant que candidate principale d\u00e9sign\u00e9e \u2014 et \u00e0 la Dre Jennifer Flemming (pr\u00e9sidente du comit\u00e9 des lignes directrices) en tant que candidate principale et coresponsable de l\u2019objectif 1.<\/em><\/h3>\n\n\n\n
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Concours:<\/strong> Subvention d'\u00e9quipe des IRSC : Adopter la diversit\u00e9 pour atteindre la pr\u00e9cision et l'\u00e9quit\u00e9 en sant\u00e9\/Subvention<\/p>\n\n\n\n

Titre:<\/strong> \u00c9quipe Liver AI \u2013 \u00c9laboration d'un cadre pour lutter contre les in\u00e9galit\u00e9s d'acc\u00e8s et de r\u00e9sultats pour les personnes n\u00e9cessitant une transplantation h\u00e9patique au Canada<\/p>\n\n\n\n

Demandeur principal d\u00e9sign\u00e9 :<\/strong> Docteur Mamatha Bhat<\/p>\n\n\n\n

Co-candidats principaux :<\/strong> Dre Jennifer Anne Flemming Dre Patricia Gongal, professeur Rahul Gopalkrishnan Dre Divya Sharma<\/p>\n\n\n\n

Co-demandeurs :<\/strong> Dr S. Berkhout, Dr R. Bhanji, Prof. M. Brudno, Dr D. Chahal, Dr P. Chaudhury, Dr S. Congly, Dr J. Feld, MJ Gross, Prof. G. Hirschfield, Mme S. Holdsworth Dr G. Huard, Mme S. Jha, Dr M. Khan, Dr S. Naimimohasses, Mme S. Raju, Dr M. Selzner, Dr A. Shaheen, Mme M. Vyas, Mme G. Wright, Mx. J. Zhao, Dr X. Zhao, Dr J. Zhu, Dr E. Ziegler<\/p>\n\n\n\n

R\u00e9sum\u00e9 de la proposition de recherche<\/strong><\/h2>\n\n\n\n

Les maladies chroniques du foie touchent plus de trois millions de Canadiens, et plus de 5\u00a0000 d'entre eux en meurent chaque ann\u00e9e. La transplantation h\u00e9patique (TH) repr\u00e9sente un traitement vital et salvateur pour les maladies du foie en phase terminale. Cependant, l'acc\u00e8s \u00e0 la transplantation h\u00e9patique et ses r\u00e9sultats doivent \u00eatre r\u00e9form\u00e9s de toute urgence, compte tenu des obstacles profond\u00e9ment ancr\u00e9s \u00e0 l'\u00e9quit\u00e9 des soins. Une approche transformatrice est essentielle pour \u00e9liminer les in\u00e9galit\u00e9s sociales et sanitaires qui entravent l'acc\u00e8s \u00e0 des r\u00e9sultats justes et \u00e9quitables pour tous. L'innovation gr\u00e2ce \u00e0 des technologies comme l'intelligence artificielle (IA) est \u00e0 la fois prometteuse pour faire progresser les soins cliniques et comme moyen de lutter contre les in\u00e9galit\u00e9s en mati\u00e8re de soins de sant\u00e9. De m\u00eame, il est n\u00e9cessaire d'instaurer un climat de confiance pour favoriser l'engagement des m\u00e9decins et des patients.<\/p>\n\n\n\n

Gr\u00e2ce \u00e0 cette subvention d'\u00e9quipe, nous aborderons les d\u00e9fis cruciaux de l'\u00e9quit\u00e9 tout au long du parcours des patients ayant subi une transplantation h\u00e9patique (TH) au Canada, en utilisant des mod\u00e8les avanc\u00e9s et des approches de pr\u00e9cision issues de l'IA de pointe. Ce faisant, nous fournirons une plateforme \u00e9quitable et inclusive qui optimisera les r\u00e9sultats pour les patients. Nous allons\u00a0:<\/p>\n\n\n\n

    \n
  1. D\u00e9limiter les disparit\u00e9s dans l\u2019orientation vers une transplantation h\u00e9patique au Canada (Objectif 1).<\/li>\n\n\n\n
  2. D\u00e9velopper un mod\u00e8le pour assurer une attribution juste et \u00e9quitable des organes aux patients figurant sur la liste d\u2019attente pour une transplantation h\u00e9patique (Objectif 2).<\/li>\n\n\n\n
  3. D\u00e9velopper un mod\u00e8le pr\u00e9dictif pour guider la pr\u00e9servation de la sant\u00e9 du greffon apr\u00e8s la transplantation, en int\u00e9grant les d\u00e9terminants m\u00e9dicaux et socio-\u00e9conomiques de la sant\u00e9 (Objectif 3).<\/li>\n\n\n\n
  4. Aborder de mani\u00e8re collaborative les d\u00e9fis en mati\u00e8re d\u2019\u00e9quit\u00e9 dans la transplantation h\u00e9patique par le biais de dialogues critiques nationaux (objectif 4).<\/li>\n<\/ol>\n\n\n\n

    Notre \u00e9quipe nationale diversifi\u00e9e, compos\u00e9e de m\u00e9decins, de scientifiques informaticiens, d'\u00e9thiciens, d'infirmi\u00e8res et de patients partenaires profond\u00e9ment engag\u00e9s, est unie dans la mission de construire un cadre national durable pour un acc\u00e8s plus \u00e9quitable aux r\u00e9f\u00e9rences de transplantation h\u00e9patique et aux offres d'organes pour les patients en liste d'attente, tout en optimisant les r\u00e9sultats post-transplantation pour tous les receveurs.<\/p>\n\n\n\n

    Afin de cartographier le paysage actuel des orientations vers les programmes de transplantation h\u00e9patique, nous analyserons les donn\u00e9es sur la pr\u00e9valence de l'h\u00e9patite C terminale au Canada, en les corr\u00e9lant au nombre d'orientations et de transplantations selon le sexe, la race\/l'origine ethnique et les d\u00e9terminants sociaux de la sant\u00e9 (Objectif 1). Pour rem\u00e9dier aux profondes in\u00e9galit\u00e9s dans l'attribution des organes, notre \u00e9quipe multidisciplinaire \u00e9laborera un mod\u00e8le statistique permettant de pr\u00e9dire la probabilit\u00e9 que chaque patient re\u00e7oive une offre de don, ce qui nous permettra de proposer des strat\u00e9gies cibl\u00e9es pour une distribution plus \u00e9quitable des organes (Objectif 2). Fond\u00e9e sur une compr\u00e9hension intersectionnelle des disparit\u00e9s en mati\u00e8re de sant\u00e9, qui conceptualise les cat\u00e9gories sociales de diff\u00e9rence comme \u00e9tant interactives et mutuellement informatives, notre approche r\u00e9flexive et it\u00e9rative de collecte et d'analyse des donn\u00e9es vise \u00e0 garantir \u00e0 chaque patient une chance \u00e9quitable de recevoir une transplantation.<\/p>\n\n\n\n

    Afin d'am\u00e9liorer les r\u00e9sultats \u00e0 long terme, nous exploiterons l'IA pour identifier et att\u00e9nuer les disparit\u00e9s raciales, ethniques et socio-\u00e9conomiques en mati\u00e8re de sant\u00e9 post-transplantation (Objectif 3). Afin de renforcer la confiance et la compr\u00e9hension de l'IA au sein de la communaut\u00e9, nous mettrons en place des forums nationaux con\u00e7us pour des dialogues ouverts et multidirectionnels. Ces forums permettront aux \u00e9quipes de recherche de cr\u00e9er des syst\u00e8mes \u00e9quitables et fiables (Objectif 4). En examinant les d\u00e9fis \u00e9thiques et politiques li\u00e9s \u00e0 la collecte, \u00e0 l'analyse, \u00e0 l'acc\u00e8s et \u00e0 l'utilisation des donn\u00e9es, nous aborderons les facteurs cl\u00e9s qui influencent la r\u00e9ussite de la mise en \u0153uvre de ces outils pour promouvoir l'\u00e9quit\u00e9 en sant\u00e9. Gr\u00e2ce \u00e0 ces \u00e9changes cruciaux, nous favoriserons des approches inclusives et r\u00e9flexives en mati\u00e8re de donn\u00e9es et de d\u00e9veloppement d'outils d'IA, en veillant \u00e0 ce que toutes les parties prenantes participent \u00e0 l'\u00e9laboration de solutions efficaces et fiables.<\/p>\n\n\n\n

    Nous tirerons parti du projet ECHO, une infrastructure existante et efficace, pour la diffusion des connaissances et la sensibilisation des professionnels de la sant\u00e9 en r\u00e9gion \u00e9loign\u00e9e qui orientent et cog\u00e8rent les patients atteints d'une maladie du foie. Nos collaborateurs, qui si\u00e8gent \u00e0 des associations professionnelles et \u00e0 des organismes gouvernementaux, animeront des pr\u00e9sentations aux d\u00e9cideurs politiques et renforceront le soutien \u00e0 la mise en \u0153uvre de notre nouveau mod\u00e8le d'attribution d'organes. La Soci\u00e9t\u00e9 canadienne de la CBP, PSC Partners, le Programme canadien de recherche en don et transplantation et Foie Canada soutiendront notre engagement communautaire et la mobilisation des connaissances. Gr\u00e2ce \u00e0 notre \u00e9quipe interdisciplinaire pancanadienne, nous d\u00e9velopperons des outils de d\u00e9cision clinique aliment\u00e9s par des donn\u00e9es diversifi\u00e9es afin de promouvoir l'\u00e9quit\u00e9 dans l'orientation des patients vers des services de transplantation et l'attribution des organes, tout en optimisant les r\u00e9sultats de sant\u00e9 \u00e0 long terme pour tous les Canadiens touch\u00e9s par une maladie du foie.<\/p>\n\n\n\n

    Impliquez-vous<\/strong><\/h2>\n\n\n\n

    Si vous souhaitez en savoir plus sur le projet ou participer \u00e0 nos forums nationaux, veuillez contacter Mme Katie Bain, gestionnaire de projet (katie.bain@cdtrp.ca).<\/p>\n\n\n\n

    <\/p>","protected":false},"excerpt":{"rendered":"

    Congratulations to Dr. Mamatha Bhat (CASL Research Committee Co-Chair) for leading a $2M CIHR-funded project as Nominated Principal Applicant \u2014 […]<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ngg_post_thumbnail":0,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-4755","post","type-post","status-publish","format-standard","hentry","category-casl-news"],"acf":[],"yoast_head":"\nTeam Liver AI \u2013 Building the Framework to Tackle the Inequities of Access to and Outcomes for People Needing Liver Transplant in Canada - 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